nucleoside phosphorylase

enzyme

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July 23, 2026

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Nucleoside phosphorylase is an enzyme that plays a role in nucleotide synthesis. It is involved in attaching phosphate groups to nucleosides, which are components of RNA and DNA. Specifically, it functions when cells utilize recycled purines to create nucleotides. Mutations in the gene for nucleoside phosphorylase can lead to severe immune deficiency. Another related enzyme, nucleotidase, promotes the hydrolysis of a nucleotide into a nucleoside and phosphoric acid.123

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For example, an enzyme called nucleoside phosphorylase serves this role when cells switch to synthesizing nucleotides from recycled purines instead of from new starting materials. Mutations in the gene encoding nucleoside phosphorylase can cause a severe form of immune deficiency.
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For example, an enzyme called nucleoside phosphorylase serves this role when cells switch to synthesizing nucleotides from recycled purines instead of from new starting materials. Mutations in the gene encoding nucleoside phosphorylase can cause a severe form of immune deficiency.
Read More