nortriptyline

drug

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Last updated

July 1, 2026

Quick Summary

Nortriptyline is a tricyclic antidepressant drug used to treat depression. It works by increasing the levels of neurotransmitters like serotonin and norepinephrine in the brain, which are believed to help regulate mood.1

Antidepressants, including nortriptyline, function by preventing the reabsorption or inactivation of these neurotransmitters, allowing them to accumulate and remain active for longer periods. This process is thought to be crucial in alleviating depressive symptoms. Nortriptyline was first used in 1962.12

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antidepressant
amitriptyline, desipramine, nortriptyline, and a number of other compounds. These drugs relieve symptoms in a high proportion (more than 70 percent) of depressed patients. As with the MAOIs, the antidepressant action of tricyclic drugs may not become apparent until two to four weeks after treatment begins.
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amitriptyline, desipramine, nortriptyline, and a number of other compounds. These drugs relieve symptoms in a high proportion (more than 70 percent) of depressed patients. As with the MAOIs, the antidepressant action of tricyclic drugs may not become apparent until two to four weeks after treatment begins.
Read More