noncompetitive inhibition
Quick Summary
Noncompetitive inhibition occurs when an inhibitor binds to an enzyme at a location other than the active site. This binding changes the enzyme's shape, deforming the active site and preventing it from reacting with its substrate. Unlike competitive inhibition, the inhibitor does not prevent the substrate from binding to the enzyme. This type of inhibition is often a form of negative feedback, where the end product of a metabolic pathway acts as an allosteric inhibitor on an earlier enzyme in that pathway. Enzymes are biological catalysts that regulate chemical reactions in living organisms.12
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enzymeFactors affecting enzyme activityNoncompetitive inhibition occurs when an inhibitor binds to the enzyme at a location other than the active site. In some cases of noncompetitive inhibition, the inhibitor is thought to bind to the enzyme in such a way as to physically block the normal active site.…
Read MoreNoncompetitive inhibition occurs when an inhibitor binds to the enzyme at a location other than the active site. In some cases of noncompetitive inhibition, the inhibitor is thought to bind to the enzyme in such a way as to physically block the normal active site.…
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…at some other site (noncompetitive inhibition). In the latter, the inhibitor does not prevent binding of the substrate to the enzyme but sufficiently changes the shape of the site at which catalytic activity occurs so as to prevent it.
Read More…at some other site (noncompetitive inhibition). In the latter, the inhibitor does not prevent binding of the substrate to the enzyme but sufficiently changes the shape of the site at which catalytic activity occurs so as to prevent it.
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