nonbarbiturate drug

A nonbarbiturate is a drug that is not derived from barbituric acid. These substances are used as sedative-hypnotics, meaning they can reduce tension and anxiety or induce sleep. Unlike barbiturates, nonbarbiturates generally have fewer risks of tolerance and addiction and are less likely to dangerously depress the central nervous system.123

Examples of nonbarbiturate sedative-hypnotics include benzodiazepines, such as diazepam (Valium) and alprazolam (Xanax), which are often prescribed for anxiety and insomnia. Other nonbarbiturate agents include chloral hydrate and certain antihistamines used in over-the-counter sleep aids. While effective, some nonbarbiturates can still lead to tolerance and withdrawal symptoms with prolonged use.23