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Neurotensin is a hormone secreted by the N cells in the ileum, a part of the small intestine, in response to the presence of fat. It plays a role in regulating the digestive system by influencing motility, relaxing the lower esophageal sphincter, and inhibiting the secretion of acid and pepsin stimulated by the vagus nerve. Neurotensin is considered a neurohormone, a substance produced by neurosecretory cells in the nervous system and released into the bloodstream, similar to hormones from the endocrine system.12

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