neurokinin B

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neurokinin B

signaling molecule

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fezolinetant
Mechanism of action
…by suppressing the activity of neurokinin B (NKB), a signaling molecule produced by specialized hypothalamic neurons known as KNDy neurons. During menopause, when estrogen levels fall, this inhibitory effect is lost, allowing NKB signaling through neurokinin 3 (NK3) receptors to become overactive. The resulting surges in activity overstimulate vasodilation and…
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…by suppressing the activity of neurokinin B (NKB), a signaling molecule produced by specialized hypothalamic neurons known as KNDy neurons. During menopause, when estrogen levels fall, this inhibitory effect is lost, allowing NKB signaling through neurokinin 3 (NK3) receptors to become overactive. The resulting surges in activity overstimulate vasodilation and…
Read More