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Neoblasts are large, undifferentiated cells found in annelid worms that play a crucial role in regeneration. These cells are particularly significant in flatworms, such as planarians, which are renowned for their remarkable regenerative capabilities.123

In flatworms, neoblasts are believed to be the source of cells that form new body parts, like heads and tails, when the organism is cut. These undifferentiated cells are rich in ribonucleic acid (RNA), which is essential for cell division, and they appear in large numbers during the regeneration process. While there is some debate about the exact origin of these regenerative cells, the presence and activity of neoblasts are strongly linked to the ability of these organisms to regrow lost parts.23

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