nefazodone

Nefazodone is an atypical antidepressant drug used to treat depression. It works by inhibiting the reuptake of serotonin and norepinephrine in the brain, allowing these neurotransmitters to accumulate and improve mood.1

While effective, nefazodone carries a risk of liver failure, which led to its discontinuation in the United States. Other classes of antidepressants include tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), and selective serotonin reuptake inhibitors (SSRIs). Antidepressants generally take several weeks to show significant improvement and are often prescribed for at least six months to prevent relapse.1