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The term "mucosal barrier" refers to the mucous membranes that line internal body cavities and tracts, such as the respiratory and digestive systems. These membranes are composed of epithelial cells over connective tissue and are crucial for protection and lubrication.

Mucous membranes secrete mucus, a fluid that traps inhaled particles and pathogens, preventing them from entering deeper tissues. This mucus also helps keep the underlying tissues moist. The skin acts as a mechanical barrier, while mucous membranes trap and expel foreign substances, also containing protective antibodies. This dual function makes them a vital defense against infection.

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