monovalent oral poliovirus vaccine

The monovalent oral poliovirus vaccine (mOPV1) is a preparation of live, attenuated poliovirus designed to prevent polio, an infectious disease affecting the nervous system. Unlike trivalent OPV (tOPV), which contains all three serotypes of the poliovirus, mOPV1 specifically targets and provides immunity against only serotype 1 (PV1). This specificity can increase its effectiveness, with a single dose of mOPV1 conferring immunity to PV1 in a higher percentage of children compared to a dose of tOPV. Oral poliovirus vaccines (OPV) are administered as drops and stimulate both systemic and local immune responses, with the weakened virus replicating in the intestine. While OPV has been instrumental in polio eradication efforts, it carries a rare risk of causing vaccine-derived polioviruses (VDPVs) or vaccine-associated paralytic polio (VAPP).12