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Mesoglea is a jellylike substance found between the outer ectoderm and inner endoderm of invertebrates like sponges and cnidarians. This largely noncellular layer is permeated by elastic fibers.12

In jellyfish (medusae), the mesoglea makes up the majority of the animal's body and functions as a resilient skeleton. In contrast, in polyp forms, the water-filled coelenteron acts as a hydrostatic skeleton, working with the mesoglea to maintain the animal's shape. Muscles in cnidarians are extensions of cell bases and are organized in ways that allow for elongation, shortening, and bending of the body and tentacles in polyps, and jet propulsion in medusae.2

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