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The term "mass defect" in physics refers to the difference between the mass of an isotope and its mass number. This difference, which can be positive or negative, is accounted for by the conversion of mass into binding energy when subatomic particles combine to form an atom.12

Specifically, the total mass of the bound particles in an atomic nucleus is less than the sum of the masses of the individual protons and neutrons. This difference in mass is equivalent to the nuclear binding energy, as described by Einstein's mass-energy equivalence equation, (E = mc^2). This phenomenon is crucial in understanding nuclear reactions and the stability of atomic nuclei.32

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