malonyl transacylase

enzyme

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Last updated

June 30, 2026

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Malonyl transacylase is an enzyme involved in fatty acid synthesis. It plays a role in transferring a malonyl group to the acyl-carrier protein (ACP-SH) during the process of building fatty acids from acetyl coenzyme A and malonyl coenzyme A. This transfer is a crucial step in extending the carbon chain of the developing fatty acid molecule. The enzyme's action, along with the subsequent loss of carbon dioxide, provides a thermodynamic driving force for fatty acid synthesis.1

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metabolism
Fatty acids
…known as acetyl transacylase and malonyl transacylase, respectively. Acetyl-ACP and malonyl-ACP react in a reaction catalyzed by β-ketoacyl-ACP synthetase so that the acetyl moiety (CH₃CO―) is transferred to the malonyl moiety (⁻OOCH₂CO―). Simultaneously, the carbon dioxide fixed in step [62] is lost, leaving as a product a four-carbon moiety attached…
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…known as acetyl transacylase and malonyl transacylase, respectively. Acetyl-ACP and malonyl-ACP react in a reaction catalyzed by β-ketoacyl-ACP synthetase so that the acetyl moiety (CH₃CO―) is transferred to the malonyl moiety (⁻OOCH₂CO―). Simultaneously, the carbon dioxide fixed in step [62] is lost, leaving as a product a four-carbon moiety attached…
Read More