male menopause

physiology

Also known as: andropause, late-onset hypogonadism

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July 20, 2026

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"Male menopause," also known as andropause or late-onset hypogonadism, refers to an age-related decline in testicular function in men, leading to testosterone deficiency. This condition typically begins around age 40 and affects about 2 percent of men. Unlike menopause in women, which involves an abrupt cessation of menstruation, male menopause progresses gradually over many years.12

Symptoms can be subtle and may include decreased libido, fatigue, depression, and erectile dysfunction. The physiological decline in testosterone is due to a decrease in androgen-secreting Leydig cells in the testes, accompanied by a gradual reduction in sperm production. While hormone therapy can treat some symptoms, there is no scientific evidence that hormone administration can slow or reverse the aging process.12

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human endocrine system
The testis
…by late-onset hypogonadism (andropause, or male menopause), which begins around age 40 and results in decreased testicular function and testosterone deficiency. Symptoms of late-onset hypogonadism include decreased libido, fatigue, depression, and erectile dysfunction. The condition may proceed unnoticed for many years because symptoms are often subtle.
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…by late-onset hypogonadism (andropause, or male menopause), which begins around age 40 and results in decreased testicular function and testosterone deficiency. Symptoms of late-onset hypogonadism include decreased libido, fatigue, depression, and erectile dysfunction. The condition may proceed unnoticed for many years because symptoms are often subtle.
Read More

menopause
The term male menopause is sometimes used to describe an equivalent aging-related decline in testicular function that results in testosterone deficiency in men. This process is alternatively referred to as late-onset hypogonadism or andropause. It affects about 2 percent of men and may begin at age 40.…
Read More
The term male menopause is sometimes used to describe an equivalent aging-related decline in testicular function that results in testosterone deficiency in men. This process is alternatively referred to as late-onset hypogonadism or andropause. It affects about 2 percent of men and may begin at age 40.…
Read More