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A macromere is a large blastomere, which is a cell produced during cleavage, a series of cell divisions that occur after fertilization to form a multicellular organism from a single-celled zygote. Blastomeres are the building blocks of an embryo. The size of blastomeres can vary depending on the amount of yolk in an egg; those with more yolk tend to produce larger blastomeres. Macromeres are distinct from macronuclei, which are large nuclei found in certain protozoans that influence cell activities.123

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