lower limit of detection

measurement

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June 30, 2026

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The lower limit of detection (LLD) is a crucial characteristic of a detector, representing the smallest amount of a solute that can be measured. This measurement involves distinguishing the signal from inherent electronic noise.1

There are two types of mass-sensitive detectors:
* Moles: Used for measuring the absolute amount of solute.1
* Moles per litre: Used for measuring solute concentration.1

A second important characteristic is sensitivity, which is the change in signal intensity relative to the change in the amount of solute. The third is the linear range, where the signal intensity is directly proportional to the amount of solute.1

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chromatography
Detector characteristics
The first is the lower limit of detection, the smallest amount of solute measured in terms of moles (mass-sensitive detectors) or moles per litre (concentration-sensitive detectors) that can be detected; this entails distinguishing a signal from the random noise inherent in all electronic systems. A second is the sensitivity,…
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The first is the lower limit of detection, the smallest amount of solute measured in terms of moles (mass-sensitive detectors) or moles per litre (concentration-sensitive detectors) that can be detected; this entails distinguishing a signal from the random noise inherent in all electronic systems. A second is the sensitivity,…
Read More