lin-14

…with a gene known as lin-14. Although it was apparent to Ambros and others that lin-4 somehow regulates lin-14 activity, the mechanism was a mystery.

In 1985 Ruvkun joined the faculty at Massachusetts General Hospital and Harvard Medical School and continued to research developmental genetics in C. elegans. He successfully cloned the lin-14 gene, and in the early 1990s, following Ambros’s observation that lin-4 produces a very…