leptin

hormone

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June 17, 2026

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Leptin is a peptide hormone produced by fat cells that plays a crucial role in regulating body weight. It signals the hypothalamus in the brain to suppress appetite and increase the burning of stored fat. This hormone is involved in metabolism, bone metabolism, immunity, and reproductive functions.12

The leptin receptor, found on cell membranes and highly concentrated in the hypothalamus, receives signals from leptin. When leptin binds to these receptors, it promotes a feeling of satiety, reducing hunger. Leptin receptor deficiency can lead to persistent hunger, overeating, obesity, hypogonadism, delayed puberty, and infertility. While genetic factors influence body weight, environmental factors like diet and sedentary lifestyles also play a significant role.23

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leptin receptor
…receives and transmits signals from leptin, a hormone released from fat cells that is involved primarily in the regulation of metabolism but also serves roles in bone metabolism, immunity, and reproductive function. The leptin receptor is located in the cell membrane in various tissues in the body but is most…
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…receives and transmits signals from leptin, a hormone released from fat cells that is involved primarily in the regulation of metabolism but also serves roles in bone metabolism, immunity, and reproductive function. The leptin receptor is located in the cell membrane in various tissues in the body but is most…
Read More

nutritional disease
Obesity and weight control
…adipose (fat) tissue cells secrete leptin, a protein hormone. When fat stores increase, leptin sends a signal to the hypothalamus (a regulatory centre in the brain) that stimulates one to eat less and expend more energy. Certain genetic mutations result in insufficient production of functional leptin or in a failure…
Read More
…adipose (fat) tissue cells secrete leptin, a protein hormone. When fat stores increase, leptin sends a signal to the hypothalamus (a regulatory centre in the brain) that stimulates one to eat less and expend more energy. Certain genetic mutations result in insufficient production of functional leptin or in a failure…
Read More