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Conformation refers to the different spatial arrangements of atoms in a molecule that can be achieved by rotating around single covalent bonds. These arrangements are not fixed; molecules are dynamic and can change shape.1

Isomerism describes molecules with the same chemical formula but different structures or spatial arrangements, leading to different properties. Isomerization is the process where a compound transforms into one of its isomers.23

Conformational isomers are a type of stereoisomer that can interconvert through rotation around single bonds. However, some rotations require significant energy, making interconversion difficult or impossible under normal conditions. The stability of different conformations varies due to attractive and repulsive forces between atoms. Molecules tend to occupy their most stable, lowest-energy conformations.41

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