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immune serum globulin

biology
Also known as: ISG

Quick Summary

Immune serum globulin (ISG) is a blood product derived from the plasma of healthy donors. It contains a mixture of immunoglobulins, primarily IgG, with smaller amounts of IgM and IgA. These immunoglobulins are also known as gamma globulins and play a crucial role in the body's immune system by acting as antibodies.132

ISG is used to provide passive immunity, offering temporary protection against various diseases such as measles and hepatitis A. It is also vital for individuals with agammaglobulinemia or hypogammaglobulinemia, conditions characterized by an inadequate supply of gamma globulin, which impairs their ability to fight infections. Intravenous immunoglobulins (IVIGs) offer a more convenient method of administration compared to painful intramuscular injections.13

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