imipenem

Imipenem is a semisynthetic antibiotic derived from the bacterium Streptomyces cattleya. It belongs to the carbapenem class and is effective against both gram-negative and gram-positive bacteria. Imipenem functions by interfering with bacterial cell wall synthesis and is highly resistant to most enzymes that break down beta-lactam antibiotics.12

Because imipenem is not absorbed from the gastrointestinal tract, it must be administered via intramuscular injection or intravenous infusion. It is typically given with cilastatin, an enzyme inhibitor that prevents imipenem from being broken down in the kidneys. However, neurotoxicity and seizures have been noted as potential side effects that can limit its use.2