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Imidazole is a class of organic compounds characterized by a ring structure containing three carbon atoms and two nitrogen atoms at nonadjacent positions. The simplest member of this family is imidazole itself, with the molecular formula C3H4N2. Imidazole compounds are biologically significant, with the amino acid histidine and its decomposition product histamine featuring the imidazole structure. Biotin, a growth factor, also contains this ring. The first imidazole compound was prepared in 1858.12

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