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hypogammaglobulinemia

pathology

Quick Summary

Hypogammaglobulinemia is a condition where the body has an inadequate supply of gamma globulins, which are a subgroup of blood proteins that include antibodies. This deficiency means individuals cannot develop sufficient immunity to infectious diseases, leading to frequent infections.1

Gamma globulins, specifically immunoglobulins, are crucial for the body's defense system. When the body forms antibodies, they are found within the gamma globulins. In cases of hypogammaglobulinemia, the reduced levels of these antibodies impair the immune response.1

Immune serum globulin (ISG), derived from healthy donors, contains a mix of immunoglobulins and can be used to treat hypogammaglobulinemia, providing passive immunity. Intravenous immunoglobulins (IVIGs) offer a way to quickly increase antibody levels.2

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