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The hypoblast is a layer of cells that forms during early embryonic development in some animals, including reptiles, birds, and mammals. It is one of the first cell layers to differentiate from the inner cell mass of the blastocyst.12

In mammals, the hypoblast is formed from cells that arrange into a layer facing the blastocyst cavity. This layer contributes to the formation of the embryonic endoderm, which eventually develops into the respiratory and digestive tracts. The hypoblast is also referred to as the endoderm of an embryo. The term "hypoblastic" describes something related to or derived from the hypoblast.3245

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