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Hypercalcemia is a condition characterized by an excess of calcium in the blood. This can occur due to primary hyperparathyroidism, where the parathyroid glands secrete too much parathormone, leading to increased calcium levels by breaking down bone and reabsorbing calcium in the kidneys. It can also be secondary, occurring when the parathyroid glands overcompensate for low calcium levels, often due to vitamin D deficiency or kidney disease.12

Symptoms can range from mild or absent to fatigue, weakness, depression, nausea, vomiting, constipation, bone pain, and kidney stones. Treatment for symptomatic hypercalcemia may involve surgery to remove the cause, intravenous fluids, or medications like bisphosphonates.2

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  1. hyperparathyroidism
  2. hypercalcemia

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