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The horizontal duodenum is one of the four segments of the duodenum, which is the first part of the small intestine. It receives partially digested food from the stomach and begins nutrient absorption. The horizontal duodenum, situated between the liver, pancreas, and major blood vessels, can be compressed in severely thin individuals, potentially causing pain, nausea, and vomiting. While primary cancer of the duodenum is rare, benign tumors and cancers of nearby organs like the pancreas or bile duct can affect it. Inflammation of the duodenum, known as duodenitis, is often caused by the bacterium Helicobacter pylori and can lead to peptic ulcers.12

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