• Alzheimer disease

  / Genetic variants
• nervous system

  / Dominance of the cerebrum
• REM sleep

  / Features
• spatial memory

  / Areas of the brain involved in spatial memory

• Edvard I. Moser
• May-Britt Moser
• John O’Keefe

Texts

Detailed information on hippocampal structure and function is presented in Per Andersen et al. (eds.), The Hippocampus Book (2006). The role of the hippocampus in memory specifically is examined in Daniel L. Schacter and Endel Tulving (eds.), Memory Systems 1994 (1994). An early exploration of the hippocampus and spatial memory is John O’Keefe and Lynn Nadel, The Hippocampus as a Cognitive Map (1978).

Key papers

Key research papers on the subject of the hippocampus, its role in memory and spatial navigation, and the significance of hippocampal dysfunction are William Beecher Scoville and Brenda Milner, “ Loss of Recent Memory After Bilateral Hippocampal Lesions ,” Journal of Neurology, Neurosurgery & Psychiatry, 20(1):11–21 (1957); D. Marr, “ Simple Memory: A Theory for Archicortex ,” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 262(841):23–81 (1971); and Brenda Milner, Larry R. Squire, and Eric R. Kandel, “ Cognitive Neuroscience and the Study of Memory ,” Neuron, 20(3):445–468 (1998).

Scholarly reviews

Scholarly reviews summarizing research findings on various aspects of hippocampal anatomy and function include James L. McClelland, Bruce L. McNaughton, and Randall C. O’Reilly, “ Why There Are Complementary Learning Systems in the Hippocampus and Neocortex: Insights from the Successes and Failures of Connectionist Models of Learning and Memory ,” Psychological Review, 102(3):419–457 (1995); Howard Eichenbaum et al., “ The Hippocampus, Memory, and Place Cells: Is It Spatial Memory or a Memory Space? ,” Neuron, 23(2):209–226 (1999); Malcolm W. Brown and John P. Aggleton, “ Recognition Memory: What Are the Roles of the Perirhinal Cortex and Hippocampus? ,” Nature Reviews Neuroscience, 2:51–56 (2001); and Michael A. Yassa and Craig E.L. Stark, “ Pattern Separation in the Hippocampus ,” Trends in Neurosciences, 34(10):515–525 (2011).