high endothelial venule

blood vessel

Also known as: HEV

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The Information Architects of Encyclopaedia Britannica

Last updated

July 16, 2026

Quick Summary

High endothelial venules (HEVs) are specialized blood vessels within lymph nodes. They play a crucial role in the immune system by facilitating the entry of lymphocytes, specifically B and T cells, from the bloodstream into the lymph node. These large endothelial cells have unique surface receptors that bind to lymphocytes, allowing them to migrate into the lymph node's paracortex. This process is essential for the immune system to effectively monitor the body for foreign antigens and initiate an immune response.1

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lymph node
…through specialized blood vessels called high endothelial venules (HEVs). HEVs contain a single layer of large endothelial cells that possess surface receptors specific for B and T lymphocytes. As these cells pass through the HEVs, they bind to the receptors and are carried into the paracortex of the lymph node.
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…through specialized blood vessels called high endothelial venules (HEVs). HEVs contain a single layer of large endothelial cells that possess surface receptors specific for B and T lymphocytes. As these cells pass through the HEVs, they bind to the receptors and are carried into the paracortex of the lymph node.
Read More