hierarchical shotgun sequencing
Quick Summary
Hierarchical shotgun sequencing is a method used in whole genome sequencing to determine an organism's complete genetic code. This approach involves breaking down the large genome into smaller, manageable fragments. These fragments are then arranged into ordered arrays, forming physical maps. These maps help to organize the fragments, allowing them to be aligned and pieced together based on overlapping sequences, ultimately reconstructing the full-length genomic sequence. This method was crucial for projects like the Human Genome Project, enabling the sequencing of large and complex genomes by breaking them into smaller, ordered pieces before sequencing.1
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