hemoglobin S
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Hemoglobin S is an abnormal type of hemoglobin found in red blood cells, primarily associated with sickle cell anemia and sickle-cell trait. Hemoglobin, in general, is an iron-containing protein in red blood cells responsible for transporting oxygen from the lungs to the tissues.12
In sickle cell anemia, the abnormal hemoglobin (hemoglobin S) causes red blood cells to become crescent-shaped when oxygen levels are low. These sickle-shaped cells can obstruct blood flow in small vessels, leading to tissue damage. This condition is a hereditary anemia where the abnormal sickle-shaped cells have a shorter lifespan and are prematurely destroyed. The gene responsible for sickle cell anemia, when inherited from both parents, results in a serious and potentially fatal disease. The sickle cell trait, however, where only one copy of the gene is inherited, offers some protection against malaria.234
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sickle cell anemiaCause and underlying mechanismsā¦tissues of the body, called hemoglobin S (HbS). HbS is sensitive to deficiency of oxygen. When the carrier red blood cells release their oxygen to the tissues and the oxygen concentration within those cells is reduced, HbS, in contrast to normal hemoglobin (HbA), becomes stacked within the red cells inā¦
Read Moreā¦tissues of the body, called hemoglobin S (HbS). HbS is sensitive to deficiency of oxygen. When the carrier red blood cells release their oxygen to the tissues and the oxygen concentration within those cells is reduced, HbS, in contrast to normal hemoglobin (HbA), becomes stacked within the red cells inā¦
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blood diseaseThalassemia and hemoglobinopathiesā¦results in the formation of Hb S (the hemoglobin of sickle cell disease) instead of Hb A. This variant hemoglobin is inherited as a Mendelian recessive trait. Thus, if only one parent transmits the gene for Hb S, the offspring inherits the trait but is harmed relatively little; the redā¦
Read Moreā¦results in the formation of Hb S (the hemoglobin of sickle cell disease) instead of Hb A. This variant hemoglobin is inherited as a Mendelian recessive trait. Thus, if only one parent transmits the gene for Hb S, the offspring inherits the trait but is harmed relatively little; the redā¦
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