granulation tissue

physiology

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July 21, 2026

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Granulation tissue is a temporary replacement for lost tissue in a wound. It is characterized by the formation of minute red granules, which are new capillaries, on the surface of a healing wound. This process is part of the body's inflammatory response to injury.123

When tissue damage occurs, the body initiates a defense mechanism to eliminate the injurious agent and remove damaged components to begin healing. In cases of substantial tissue damage where regeneration isn't fully possible, repair occurs. This involves the formation of granulation tissue, which is a delicate, vascularized connective tissue made up of new blood vessels and fibroblasts producing collagen. This tissue eventually forms a scar.3

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inflammation
Healing and repair
…vascularized connective tissue is called granulation tissue. It derives its name from the small red granular areas that are seen in healing tissue (e.g., the skin beneath a scab). As repair progresses, new blood vessels establish blood circulation in the healing area, and fibroblasts produce collagen that imparts mechanical strength…
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…vascularized connective tissue is called granulation tissue. It derives its name from the small red granular areas that are seen in healing tissue (e.g., the skin beneath a scab). As repair progresses, new blood vessels establish blood circulation in the healing area, and fibroblasts produce collagen that imparts mechanical strength…
Read More