glutamic acid decarboxylase

enzyme

Also known as: GAD

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Last updated

June 29, 2026

Quick Summary

Glutamic acid decarboxylase (GAD) is an enzyme that plays a crucial role in the central nervous system. It is responsible for converting glutamate into gamma-aminobutyric acid (GABA). GABA is an inhibitory neurotransmitter, meaning it reduces the activity of nerve cells.1

GAD is particularly important because the concentrations of GABA and GAD are closely related within the nervous system. This enzyme is essential for maintaining the balance of excitatory and inhibitory signals in the brain, contributing to functions such as regulating mood, sleep, and muscle tone.1

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nervous system
Amino acids
…from glutamate by the enzyme glutamic acid decarboxylase (GAD). Consequently, the concentrations of GABA and GAD parallel each other in the nervous system.
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…from glutamate by the enzyme glutamic acid decarboxylase (GAD). Consequently, the concentrations of GABA and GAD parallel each other in the nervous system.
Read More