glucose 1-phosphate

chemical compound

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June 29, 2026

Quick Summary

Glucose-1-phosphate is a chemical compound, specifically an ester of glucose with the formula C₆H₁₃O₉P. It plays a crucial role in metabolism, particularly in the breakdown of glycogen, the stored form of glucose in animals.12

When glycogen is broken down, glucose-1-phosphate is formed and then converted into glucose-6-phosphate. This process is essential for providing immediate energy and maintaining blood glucose levels. Glucose-1-phosphate is also involved in the synthesis of glycogen, where it acts as a carrier of glucose units. This compound is distinct from glucose-6-phosphate, though both are phosphate esters of glucose. The term "glucose phosphate" can refer to either glucose-1-phosphate or glucose-6-phosphate.234

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glycogenolysis
…released from glycogen comes from glucose-1-phosphate, which is formed when the enzyme glycogen phosphorylase catalyzes the breakdown of the glycogen polymer. In the liver, kidneys, and intestines, glucose-1-phosphate is converted (reversibly) to glucose-6-phosphate by the enzyme phosphoglucomutase. Those tissues also house the enzyme glucose-6-phosphatase, which converts
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…released from glycogen comes from glucose-1-phosphate, which is formed when the enzyme glycogen phosphorylase catalyzes the breakdown of the glycogen polymer. In the liver, kidneys, and intestines, glucose-1-phosphate is converted (reversibly) to glucose-6-phosphate by the enzyme phosphoglucomutase. Those tissues also house the enzyme glucose-6-phosphatase, which converts
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metabolism
Release of glucose from glycogen
The products of [16] are glucose 1-phosphate and chains of sugar molecules shortened by one unit; the chains are degraded further by repetition of step [16]. When a bridge linking two chains, at C1 and C6 carbon atoms of adjacent glucose units, is reached, it is hydrolyzed in a reaction…
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The products of [16] are glucose 1-phosphate and chains of sugar molecules shortened by one unit; the chains are degraded further by repetition of step [16]. When a bridge linking two chains, at C1 and C6 carbon atoms of adjacent glucose units, is reached, it is hydrolyzed in a reaction…
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Carl Cori and Gerty Cori
…discovered (1936) the activated intermediate, glucose 1-phosphate (phosphate bound to a specific carbon atom on the glucose molecule), known as the “Cori ester.” They demonstrated that it represents the first step in the conversion into glucose of the animal storage carbohydrate glycogen, large quantities of which are found in the…
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…discovered (1936) the activated intermediate, glucose 1-phosphate (phosphate bound to a specific carbon atom on the glucose molecule), known as the “Cori ester.” They demonstrated that it represents the first step in the conversion into glucose of the animal storage carbohydrate glycogen, large quantities of which are found in the…
Read More