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Gliadin is a type of protein found in wheat and other cereal grains, making up a key component of gluten. It is classified as a prolamin, meaning it is insoluble in water but soluble in alcohol-ethanol mixtures. Gliadin is characterized by its high content of the amino acids proline and glutamine, and a low content of lysine.123

This protein is significant because it is the gliadin portion of gluten that triggers an immune response in individuals with celiac disease, a hereditary intestinal disorder. Gluten's elastic network, formed by gliadin and glutenin, is crucial for the leavening of baked goods.41

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