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Gas exchange is the physiological process by which oxygen and carbon dioxide move between the air and the blood across specialized surfaces in the lungs. The human lungs provide a vast internal surface area, approximately 50–100 square meters, with extremely thin membranes (about 0.5 μm) to facilitate this exchange efficiently.1

This vital process occurs through two main mechanisms: convection (mass flow) for moving air and blood, and diffusion for gas transfer across membranes. Diffusion is driven by differences in the partial pressures of gases, with gases moving from areas of higher pressure to lower pressure.1

Oxygen is primarily transported in the blood bound to hemoglobin within red blood cells, while carbon dioxide is transported in several forms, including dissolved in plasma, bound to proteins, and predominantly as bicarbonate ions. This exchange is crucial for supplying tissues with oxygen and removing carbon dioxide, supporting cellular metabolism.231

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