ganglioside
Quick Summary
Gangliosides are a group of glycolipids found in the plasma membrane of cells, particularly in the gray matter of the brain. They were first isolated from brain ganglia, hence their name.1
These lipids play a role in lipid storage diseases, which are hereditary disorders where specific lipids accumulate in the body due to enzyme defects. In Tay-Sachs disease, for example, gangliosides build up in the central nervous system, leading to severe mental deficiency and deterioration.2
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- lipid storage disease
…disease, or amaurotic (blind) idiocy, gangliosides are deposited in body tissues, chiefly those of the central nervous system, which deteriorates, resulting in severe mental deficiency. Characteristic early symptoms of Tay-Sachs disease include extreme sensitivity to noise, muscle weakness, and the appearance of a cherry-red spot on the small, highly sensitive…
Read More…disease, or amaurotic (blind) idiocy, gangliosides are deposited in body tissues, chiefly those of the central nervous system, which deteriorates, resulting in severe mental deficiency. Characteristic early symptoms of Tay-Sachs disease include extreme sensitivity to noise, muscle weakness, and the appearance of a cherry-red spot on the small, highly sensitive…
Read More - Tay-Sachs disease
…A allows an unusual sphingolipid, ganglioside GM2, to accumulate in the brain, where it soon exerts devastating effects on neurological function. In some affected children, the enzyme is present but the sphingolipid accumulates nonetheless. Tay-Sachs infants appear normal at birth but become listless and inattentive during the first few months…
Read More…A allows an unusual sphingolipid, ganglioside GM2, to accumulate in the brain, where it soon exerts devastating effects on neurological function. In some affected children, the enzyme is present but the sphingolipid accumulates nonetheless. Tay-Sachs infants appear normal at birth but become listless and inattentive during the first few months…
Read More