fructose diphosphatase
enzyme
Quick Summary
Fructose diphosphatase is an enzyme crucial for gluconeogenesis, the process of forming glucose from non-carbohydrate precursors. A deficiency in this enzyme impairs the body's ability to create glucose, leading to severe hypoglycemia, particularly after fasting. Symptoms can include liver enlargement and intolerance to fasting. Treatment focuses on managing hypoglycemic episodes with glucose and avoiding fasting. This enzyme is also involved in regulating metabolism, with its activity being strongly inhibited by AMP.123
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