fructose 1-phosphate kinase

Fructose 1-phosphate kinase is an enzyme that plays a role in carbohydrate metabolism, specifically in the breakdown of sugars. It is distinct from phosphofructokinase, which is a key enzyme in glycolysis.12

In some organisms, fructose 1-phosphate kinase directly converts fructose 1-phosphate and adenosine triphosphate (ATP) into fructose 1,6-diphosphate and adenosine diphosphate (ADP). This process is part of how fructose is catabolized, or broken down, to enter central metabolic pathways.3

Disorders related to fructose metabolism can occur if enzymes like fructose-1-phosphate aldolase are deficient, leading to conditions such as hereditary fructose intolerance. Fructosuria is another condition where a defect in fructokinase leads to increased fructose in the blood and urine, but it typically has no other clinical effects.45