frame-shift mutation
Quick Summary
A frameshift mutation is a genetic mutation that occurs when a number of nucleotides not divisible by three is inserted into or deleted from a DNA sequence. This alteration changes the "reading frame" of the genetic code during translation, meaning that the triplets of nucleotides (codons) that are read to build a protein are shifted.
This shift can lead to a completely different sequence of amino acids being incorporated into the protein, often resulting in a non-functional protein. Frameshift mutations are distinct from point mutations, where only a single base pair is changed.123
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- heredityMechanisms of mutation
…loss of function is a frameshift mutation, the addition or deletion of one or more DNA bases. In a protein-coding gene, the sequence of codons starting with AUG and ending with a termination codon is called the reading frame. If a nucleotide pair is added to or subtracted from this…
Read More…loss of function is a frameshift mutation, the addition or deletion of one or more DNA bases. In a protein-coding gene, the sequence of codons starting with AUG and ending with a termination codon is called the reading frame. If a nucleotide pair is added to or subtracted from this…
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point mutation…type of mutation, called a frameshift mutation, as a type of point mutation. Frameshift mutations can lead to drastic loss of function and occur through the addition or deletion of one or more DNA bases. In a protein-coding gene the sequence of codons starting with AUG (where U is the…
Read More…type of mutation, called a frameshift mutation, as a type of point mutation. Frameshift mutations can lead to drastic loss of function and occur through the addition or deletion of one or more DNA bases. In a protein-coding gene the sequence of codons starting with AUG (where U is the…
Read More