flucytosine

Flucytosine (5-FC) is unique in that it becomes active only when converted to 5-fluorouracil (5-FU) by an enzyme, cytosine deaminase, found in fungi but not present in human cells. Flucytosine inhibits RNA and DNA synthesis. 5-FC is used primarily in the treatment of systemic cryptococcal…

…mycoses, and amphotericin B and flucytosine have been used in treating subcutaneous and systemic mycoses.