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fibrin-stabilizing factor XIII
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fibrin-stabilizing factor XIII

biochemistry
Also known as: factor XIII
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Quick Summary

Fibrin-stabilizing factor XIII, also known as factor XIII, is a crucial component in the blood clotting process. It is synthesized in the liver and plays a vital role in stabilizing the fibrin clot that forms after an injury.12

When bleeding occurs, fibrinogen, a soluble protein in blood plasma, is converted into insoluble fibrin by the enzyme thrombin. Fibrin then forms a mesh that traps platelets and blood cells, creating a clot. Factor XIII acts on this fibrin mesh, cross-linking the fibrin fibers to create a stronger, more stable clot that can effectively stop bleeding. A deficiency in factor XIII can lead to difficulties in stopping bleeding.13

Summary created from Britannica articles using AI. AI can make mistakes, so verify using Britannica articles.
4 Britannica Sources
  1. bleeding and blood clotting
  2. fibrin
  3. coagulation
  4. factor X

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