familial adenomatous polyposis
Quick Summary
Familial adenomatous polyposis (FAP) is an inherited condition characterized by the development of numerous glandular polyps, primarily in the colon and rectum. This disease arises from a mutation in the APC tumor suppressor gene. If left untreated, these polyps typically become malignant. The condition is also referred to as familial polyposis.12
Ask Britannica AI about this topic
Britannica doesn't have a full article on this topic, so we've curated a list of our relevant coverage.
tumor suppressor geneOne such familial syndrome, called familial adenomatous polyposis, is a condition in which tumors of the colon arise due to an inherited mutation in the tumor suppressor gene APC.
Read MoreOne such familial syndrome, called familial adenomatous polyposis, is a condition in which tumors of the colon arise due to an inherited mutation in the tumor suppressor gene APC.
Read More
cancerOther tumor suppressor genes…the APC gene, linked to familial adenomatous polyposis coli (a hereditary form of colorectal cancer that causes thousands of polyps to form in the colon, some of which can become cancerous); the WT1 gene, involved in Wilms tumor of the kidney; the VHL gene, associated with kidney cancer and von…
Read More…the APC gene, linked to familial adenomatous polyposis coli (a hereditary form of colorectal cancer that causes thousands of polyps to form in the colon, some of which can become cancerous); the WT1 gene, involved in Wilms tumor of the kidney; the VHL gene, associated with kidney cancer and von…
Read More