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ergotism

human and animal pathology
Also known as: Saint Anthony’s fire

Quick Summary

Ergotism is a toxic condition caused by consuming grain, grain products like rye bread, or grasses infected with ergot fungus, or from the overuse of ergot-derived drugs. This disease, also known as St. Anthony's Fire, is caused by species of the fungus Claviceps, most commonly C. purpurea infecting rye.12

The fungus destroys the plant's ovaries and forms spur-like, purple-black sclerotia, which contain poisonous alkaloids. When ingested, these can lead to symptoms such as convulsions, hallucinations, miscarriage, dry gangrene, and even death. Historically, ergotism was prevalent in northern Europe during the Middle Ages. Modern grain cleaning has largely eliminated the disease, though it can still occur from contaminated flour or an overdose of ergot-derived medications used in obstetrics and for migraines. There is a theory that ergotism may have contributed to the strange occurrences during the Salem witch trials.23

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