ergotamine
Quick Summary
Ergotamine is an alkaloid derived from ergot, a fungal disease that affects cereal grasses, most notably rye. This compound is primarily used in its tartrate form to treat migraines. Ergot alkaloids, including ergotamine, are produced by the Claviceps fungus. While ergotamine's main effect is to constrict blood vessels, a derivative, dihydroergotamine, is also used for migraine treatment. Historically, ingestion of ergot-contaminated grains caused ergotism, a condition with severe symptoms like convulsions and gangrene. Modern grain processing has significantly reduced this risk, but ergot remains the source for important medications.123
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