disseminated intravascular coagulation

Disseminated intravascular coagulation (DIC) is an acquired blood disorder where platelets and clotting factors are consumed, leading to a severe deficiency and a bleeding disorder. This condition also activates the fibrinolytic system, which dissolves clots, causing the breakdown of fibrinogen and fibrin clots.1

Several underlying issues can trigger DIC, including bacteria and their products, tissue damage from injury or surgery, placental cells, a dead fetus, certain cancers, and venom from snakebites. Treatment focuses on addressing the root cause that initiated the activation of the blood coagulation system.1

While not directly about DIC, other blood disorders can involve platelet abnormalities, such as thrombocytopenia (a reduction in platelet count), which can lead to spontaneous bleeding.2