desmosome

biology

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June 25, 2026

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A desmosome is a specialized structure found on the cell membrane, particularly in epithelial cells. Its primary function is to act as a zone of adhesion, anchoring adjacent cells together. These structures are crucial for maintaining the integrity of tissues, especially those that experience mechanical stress, such as the skin, heart, and uterus. Desmosomes are a type of adhering junction, which mechanically link cells and are associated with intracellular fibers of the cytoskeleton. The term "desmosome" was introduced by Austrian anatomist Josef R. Schaffer in 1920.12

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human skin
Major layers
…appearance due to the numerous desmosomes on their surface. Studies with the electron microscope have revealed that desmosomes are symmetrical, laminated structures in which some layers are contributed by the plasma membranes of adjoining cells and some form an intercellular component.
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…appearance due to the numerous desmosomes on their surface. Studies with the electron microscope have revealed that desmosomes are symmetrical, laminated structures in which some layers are contributed by the plasma membranes of adjoining cells and some form an intercellular component.
Read More

cell
Adhering junctions
These adhering junctions are called desmosomes when occurring between cells and hemidesmosomes (half-desmosomes) when linked to the matrix. Adhering junctions distribute mechanical shear force throughout the tissue and to the underlying matrix by virtue of their association with intermediate filaments crossing the interior of the cell. The linkage of these…
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These adhering junctions are called desmosomes when occurring between cells and hemidesmosomes (half-desmosomes) when linked to the matrix. Adhering junctions distribute mechanical shear force throughout the tissue and to the underlying matrix by virtue of their association with intermediate filaments crossing the interior of the cell. The linkage of these…
Read More