dendritic cell

biology

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July 20, 2026

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Dendritic cells are antigen-presenting cells with irregular, branching processes. They play a crucial role in the immune system, particularly in peripheral immune tolerance, which prevents mature immune cells from attacking the body's own tissues.12

Dendritic cells can induce tolerance by presenting antigens without costimulatory signals. This process can lead to anergy (inactivation) or the differentiation of regulatory T cells (Tregs), which help suppress immune responses. This function is vital for distinguishing between harmful pathogens and the body's own cells, thereby preventing autoimmunity.32

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mononuclear phagocyte system
…precursors develop into monocytes and dendritic cells, phagocytic cells that are released into the bloodstream. Some monocytes and dendritic cells remain in the general blood circulation, but most of them enter body tissues. In tissues, monocytes develop into much larger phagocytic cells known as macrophages. The great majority of macrophages…
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…precursors develop into monocytes and dendritic cells, phagocytic cells that are released into the bloodstream. Some monocytes and dendritic cells remain in the general blood circulation, but most of them enter body tissues. In tissues, monocytes develop into much larger phagocytic cells known as macrophages. The great majority of macrophages…
Read More

Ralph M. Steinman
Cohn of the dendritic cell (a type of immune cell) and his elucidation of its role in adaptive immunity. Steinman’s work contributed to advances in the understanding and treatment of infections, autoimmune diseases, cancer, and graft rejection. His receipt of the Nobel Prize was deemed unprecedented because of…
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Cohn of the dendritic cell (a type of immune cell) and his elucidation of its role in adaptive immunity. Steinman’s work contributed to advances in the understanding and treatment of infections, autoimmune diseases, cancer, and graft rejection. His receipt of the Nobel Prize was deemed unprecedented because of…
Read More