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demyelinating neuropathy

pathology

Quick Summary

Demyelinating neuropathies occur when Schwann cells, which create the myelin sheath that insulates nerve axons, are damaged or migrate away from the nerve. This loss of insulation disrupts the conduction of nerve impulses.12

These conditions can be acquired, stemming from complications of diseases like diabetes or diphtheria, or from metabolic disorders, cancers, and autoimmune attacks like in Guillain-Barré syndrome. Genetic forms, such as Charcot-Marie-Tooth disease, also exist. Symptoms vary but can include weakness, sensory changes, and pain.1324

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