comparative genomic hybridization

gene diagnosis

Also known as: CGH

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July 19, 2026

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Comparative genomic hybridization (CGH) is a technique used in genetic testing to detect chromosomal abnormalities. It is often employed alongside preimplantation genetic diagnosis (PGD) during in vitro fertilization (IVF) to analyze embryos before implantation. CGH is more sensitive than fluorescence in situ hybridization (FISH) and can identify small chromosomal rearrangements, deletions, and duplications. This method helps in diagnosing genetic diseases and disorders by examining chromosomes, which are microscopic structures within cells that carry genetic information. Malformations in chromosomes can lead to various genetic diseases, including congenital abnormalities and developmental delays. CGH, along with other genetic tests like FISH and polymerase chain reaction (PCR), contributes to the precise diagnosis of these conditions.1234

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in vitro fertilization
Preimplantation genetic diagnosis
Another technique, known as comparative genomic hybridization (CGH), may be used in conjunction with PGD to identify chromosomal abnormalities. CGH is more sensitive than FISH and is capable of detecting a variety of small chromosomal rearrangements, deletions, and duplications. It may also be useful in reducing the chance of…
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Another technique, known as comparative genomic hybridization (CGH), may be used in conjunction with PGD to identify chromosomal abnormalities. CGH is more sensitive than FISH and is capable of detecting a variety of small chromosomal rearrangements, deletions, and duplications. It may also be useful in reducing the chance of…
Read More