citrate synthase
Quick Summary
Citrate synthase is an enzyme that catalyzes the first step of the tricarboxylic acid (TCA) cycle, a key part of cellular respiration in most living organisms. This cycle breaks down fuel molecules like glucose into carbon dioxide and energy.1
The reaction begins when citrate synthase combines acetyl coenzyme A (acetyl CoA) with oxaloacetate to form citrate and release coenzyme A. This enzyme's activity is regulated by the cell's energy levels, being inhibited by ATP in higher organisms and by reduced NAD+ in many microorganisms.123
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metabolismFormation of coenzyme A, carbon dioxide, and reducing equivalent…reaction [38] is catalyzed by citrate synthase. (As mentioned above, many of the compounds in living cells that take part in metabolic pathways exist as charged moieties, or anions, and are named as such.) Citrate undergoes isomerization (i.e., a rearrangement of certain atoms constituting the molecule) to form isocitrate [39].…
Read More…reaction [38] is catalyzed by citrate synthase. (As mentioned above, many of the compounds in living cells that take part in metabolic pathways exist as charged moieties, or anions, and are named as such.) Citrate undergoes isomerization (i.e., a rearrangement of certain atoms constituting the molecule) to form isocitrate [39].…
Read More- metabolismEnergy state of the cell
Citrate synthase, the first enzyme of the TCA cycle, is inhibited by ATP in higher organisms and by reduced NAD+ in many microorganisms. In some strictly aerobic bacteria, the inhibition by reduced NAD+ is overcome by AMP.
Read MoreCitrate synthase, the first enzyme of the TCA cycle, is inhibited by ATP in higher organisms and by reduced NAD+ in many microorganisms. In some strictly aerobic bacteria, the inhibition by reduced NAD+ is overcome by AMP.
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